ADCs vs Bruisers/Assassins
I used to miss the good old days of Kassadin and Udyr being the most OP champs in league. Now I can't even blow up an Ashe using Talon.
The imbalance isn't ADCs, it's all the item actives/passives combined with lifesteal that let them eat damage that would melt a late game Volibear.
Runes and masteries aren't going to change the itemization of supports and tanks that allow ADCs to live indefinitely, toss in GA and to the better marksman, GG.