Nasus build I thought of and will post results of later.
What if in lane you aren't playing around stacking or afk pushing but try to play more as a tank in lane that can turn the lane around after 1 item?
You max E but try to engage with the enemy laner and beat their faces in while actually farming (not stacking, that's just a bonus).
Maxing E gives you a fallback pattern to farm and reduces the enemy armor by a lot.
The runes and masteries would be flat ad reds and quints, armor per level or flat armor yellows, and whatever you want for blues.
You rush
and then you build either
or
second.
You can get any kinds of boots you want.
You run Bond of Stone or whatever the hell the new keystone is called. You need
later for your ult and E to slow and proc the mastery.
Then you can buy
early if fed or later if not fed.
Sample full build looks like

Thoughts before i try this later in a normals?