2 Item Vayne > Any other 6 Item Melee champ
Bork + Zerkers and proceed to 1v1 any melee champion in the game
Bork + Zerkers and proceed to 1v1 any melee champion in the game
unless that melee is...

Vayne can just condemn Xin away after his E
Lol I play Talon alot. Vayne wrecks me in most cases. If Vayne is skilled, she can dodge my W, dodge at least 1 R, and then kite/E me.
Even if she doesn't dodge, she can survive my full burst, unless I'm very fed. Almost anyone can survive Talon's burst these days :/ his E is only gap closer, and you use it to engage.

<- I can't think of a case, when any squishee doesn't have at least one of these..
EDIT: btw, I don't think
has the damage to kill Vayne right now. I may be wrong tho.
unless that melee is...
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jax xin talon and kassadin will just be condemned back. other can kill vayne of course
6 item melee vs 2 item vayne...all of these would easily kill her in the scenario given...
Jax leaps on her and stuns..she is dead in 2-3 hits (if she condemns faster than he can use the stun he just kites out of her range until it is back up, his cd is shorter)
Xin with
yeah Vayne stands 0 chance (and similar to Jax, his gap closer is a shorter cd than vayne's condemn even before the cdr is taken into account)
Talon will easily burst her out (pop Yomuu's and ult. You think she has the reaction time to condemn him faster than he can burst her with that advantage?)
Kassadin is condemned back...then ults on top of her again...and again...and again (6 items...he is at least level 16)
Currently abusing this to plat.
You're going to have a much harder time when you get to an elo where people don't just let you farm up a Sated Devourer.
laughs and 2shots.
Lmao as a Nasus main I just pictured this happening!

Got bored, sure there's more that just kill Vayne and teabag her with a 4 item lead.
Fighting cancer WITH cancer?
Who would've thought?
'Cept Hec and Kha though, they're not that bad.
Ranged duelist is good at dueling. Film at 11.
a good
cant even deny that one
eat oranges and be k.(i just like gangplank i know he cant)

How is she going to kite him when his E is on a bigger range than her AA?
Its actually funny that you mention this. Vayne is 100% single target sustained damage. Meaning you can burst her down, I always enjoy picking burst AD carries and 2 shotting her before she gets a single W proc on me.
HA
Do you ever post anything worth reading?
I played a game as our friendly neighborhood 
They had a vayne jungle, who didn't have devourer. I decided to ambush her. TWICE.
Let's just say I have never been more satisfied about killing a vayne.
the second time the vayne even knew what I was doing, but did nothing to stop it

Will I at least do a little okay? :/

Oh really?
master yi can't do shit against vayne, fiora can due to her ulti