a Tank with sustain in lane and unlimited damage that can even get tankier and goes URF for 15 secs when he presses R.
Building armor to reduce his damage? no problem, max "E" for poke + magic damage + shredding their armor.
???
Critmaster Garen3 votesyou stay out of his q range.
also, nasus isnt a tank.
EbonyBladeJ882 votesCorrect. He's a Juggernaut.
https://66.media.tumblr.com/d62a1e3a89515582be78577afaef5576/tumblr_miui0touxh1qd4q8ao1_500.gif
But in response to the OP...
Also, play someone who has a strong early game and bully him out of lane so as to reduce the stacks he can farm.
Some viable choices below:
Tychusfindlay9181 votesCorrect. He's a Juggernaut.
https://66.media.tumblr.com/d62a1e3a89515582be78577afaef5576/tumblr_miui0touxh1qd4q8ao1_500.gif
But in response to the OP...
Also, play someone who has a strong early game and bully him out of lane so as to reduce the stacks he can farm.
Some viable choices below:
Eh Darius just isn't that great anymore.
EbonyBladeJ881 votesDo you HAVE to rain on my parade? [sg-soraka]
Besides, I still do well against Susan as the Dunkmaster...
Except in cases where I have to 
down to bot-lane and save my "wonderful" ADC's butt and he gets to farm unimpeded. (Which is happening ALL TOO OFTEN lately because it's "Whoever wins bot, wins the game" right now. [slayer-jinx-unamused] )
Tychusfindlay9181 votesDo you HAVE to rain on my parade? [sg-soraka]
Besides, I still do well against Susan as the Dunkmaster...
Except in cases where I have to
you probably face bad nasii because he can just put three points into E and play safe until his much stronger level 6 spike if he really needs to, and there's NOTHING darius can do against that without Jungle intervention.
EbonyBladeJ881 votesWell, most of the ones I face are L7 Mastery ... and I'm an L7 Darius, so... maybe I just get lucky? https://i.giphy.com/media/13Qumr2SLqrl5e/giphy.gif
Shuriman Curator2 votesWalk out of his E?
Bait his ult?
NCBuckets2 voteshonestly the only way u can bait his ult is by using all of your cooldowns and possibly uor hp. the same thing applies with tryndamere.
KVbqbFsC8e1 votesKite him.
Warhammer Titan1 votesCamp him because he has no escapes.
Takazaki1 votes 
(maybe, in theory it should work out )
just bully the shit out of him, he sint difficult to kill in lane as Q stack nasus
also if your jungler is strong let him give him the work 
ZapMyHeart1 votesMostly slows or other CC. If you have a DPS mage who can consistently apply Rylai's, it would make him cry.
Jbels1 votesWhen the hell are people going to stop confusing tanks with Juggernauts?
DunkinNoobs1 votesYou ever played against an Illaoi? It's like that. Bait out the ult, disengage, and then re-engage when it's down. Wither makes this a little harder but it's still doable.
Xion The XIV1 votesWhen I am against a Nasus I go with the good old fall back of Dr. Mundo(
) He has a health regen on his pass well meet my Q that does % hp each. You use your W and E on me. Meet my Q that slows you just as much. And the fact Nasus can never bully a Mundo out of lane, unless he has insane stacks early on.
A lot of people will say Teemo can easily beat Nasus, but once Nasus has 100 stacks Teemo now becomes a stack.
