Predator will be extremely good thanks to rune separation
Now that macro oriented champions, typically juggernauts like Nasus and Volibear and Garen, no longer have to suffer inefficient starting stats if they run this rune, I suspect this rune will become a VERY strong alternative or maybe their main key stone depending on season 9's meta.
Predator is a very underrated key stone for laning champions particularly in top; the map presence it gives you is only surpassed by Teleport. It also allows you to use it early game to follow an invade or collapse or return to your lane sooner, either without using teleport (e.g lane hasn't crashed to your side but you don't want to give them enough time to shove and deny) or using Predator to substitute teleport (which would probably be fine in soloQ)
The power of the rune for junglers is obvious. I suspect this might also open the rune to roaming mids and supports as well.
Tl;dr predator meta in preseason