Some examples of strong level one abilities;
Ahri double hit is 80 base damage, often having enough AP at level one to push that to 100 AOE.
Anivia Q can double hit for 120 base damage at level one (AoE) and includes a stun, an experienced Anivia player often hits them.
Annie Q has 80 base damage with always enough AP to push that to 100, and it is point and click with a short cooldown.
Even more obnoxious than Annie Q is Pantheon Q with even shorter cooldown and even more potential damage.
I don't know if Azir counts but soldiers have a 60 base damage so even without AP that is 120 damage with 2 hits, technically AOE.
Caitlyn Q has a 30 base damage with 130% total AD scaling so that is almost always over 100.
Darius Q is the same way as Cait Q with base AD alone taking it to over 100 damage AOE, with healing.
If we count auto attack based abilities like Azir soldiers, Draven Q can take his auto attacks to over 100 at level one. Auto attacks are not dodgeable like Ez Q, and have "less cooldown" obviously.
Ekko Q double hit is 100 base damage AOE.
These were only some examples of easy ways to land over 100 damage at level one, and do not account the new runes which add even more damage, and do not account abilities like Miss Fortune Q bonus damage which can go to 150 or more and Fiddlesticks drain which has a base damage of 400 damage at level one over the full duration.