Using math to compare New Locket (PBE) and Old Locket (Live)
Equation: (100/(100 - X)) x H = Effective Health.
X is your damage reduction as a raw number, removing the % sign. H is your health (and let's include shields for that sake). We'll be using physical damage for the example because bruisers and adcs deal physical damage. Using level 12 and 2.5 items plus boots as Varus, Kled, and Ornn.
Varus - Level 12 - 1346 HP, 65 Armor (40% pDR)
Aatrox - Level 12 - 2182 HP, 114 Armor (53% pDR, not counting Ninja Tabi's passive) - Conditioning Rune Bonus, Ninja Tabi, Trinity Force, Sterak's Gage. Sterak's gives a 1524 decaying shield at level 12, which we'll count as a 500 shield for all sake and purpose since it is decaying.
Ornn - Level 12 - 2292 HP + 275 from W shield, 221 Armor (69% pDR, not counting Ninja Tabi's passive) - Condition Rune Bonus, Ninja Tabi, Sunfire Cape, Abyssal Mask, Bramble Vest, and Cloth Armor.
Old Locket Assuming this gives a 500 shield, we can do the math by adding that shield to the current health and running it through the equation.
Varus - (100/(100 - 40)) x 1836 = 3060 Effective Health against physical damage.
Aatrox - (100/(100 - 53)) x 3182 = 6770 Effective Health against physical damage.
Ornn - (100/(100 - 69)) x 3067 = 9894 Effective Health against physical damage.
New Locket This a bit more tricky because we have to assume the damage reduction is post resistances, rather than additive. This changes our equation to: (100/(100 - X)) x (100/(100 - 35)) x H = Effective health.
Varus - (100/(100 - 40)) x (100/(100 - 35)) x 1346 = 3451 Effective Health against physical damage.
Aatrox - (100/(100 - 53)) x (100/(100 - 35)) x 2682 = 8779 Effective Health against physical damage.
Ornn - (100/(100 - 69)) x (100/(100 - 35)) x 2567 = 12739 Effective Health against physical damage.
I don't know about you, but I'm not looking forward to a heavy CC, hypercarry meta where you lock people down so you don't have to move out of your Locket zone, and this makes Varus very good with his ult. Nor am I looking forward to a world where supports have even more control teamfights, plus this version of Locket has no downsides for enchanters who don't buy health (meaning they can get this shit and Redemption), nor is there any scaling with level at all. As a Varus player, which I know my champion is a bit strong right now, I don't want my champion murdered with nerfs.