The new Attack Move binding to your left mouse click is great....
...but it won't let you click on ANYTHING ELSE without some weird interaction going on.
If you try and buy items from the shop, your character will move to wherever you clicked while you are in the shop.
If you click on the minimap to change your camera, your character will move to wherever you clicked on the minimap (this is especially troublesome for champs who have global ultimates).
You simply can't use the ping wheel anymore, because you need to hold down your left mouse button to do that. However, once you use left click for that, it puts in the attack move command, and cancels the ping.
It's also really, really, easy to click on the wrong target, but, I'm sure this can be fixed with some practice.
Otherwise, I can already tell that it would be an AWESOME tool to have, especially for ADCs (orb walking isn't easy). But, as it stands, this needs some work for it to be a viable option.