Twitch's Contaminate feels too much like dumbed-down Kalista's Rend; A Suggestion
Hitting six stacks feels more like a punishment than a reward right now; it marks the end of your Contaminate and passive increasing in damage, not some threshold where it becomes awesome; it really should do something special at 6 stacks.
A simple fix would be to have Contaminate do true damage when used on a target with 6 stacks, similar to Rek'sai's e, but a much more awesome mechanic to add to Contaminate would be this: "At 6 stacks, the poison is Expunged, removing all stacks of Deadly Venom to deal 72 / 108 / 144 / 180 / 216 bonus true damage" (At levels 1/5/9/13/17; this is the same damage the 6 stacks would have done over their 6 seconds had they not been Expunged)
This would let Twitch's passive feel much more rewarding in extended fights, as once he applies 6 stacks he could expunge for full damage and then still be rewarded for applying it up to another 6 times.
Its a throw back to Expunge back on the 500 range Twitch I knew and loved. The ability would be so much more satisfying if the giant skull at 6 stacks meant something. It would make it feel like a unique element to his kit rather than a worse Rend.
If this is makes him too strong, a good solution would be lowering his early game passive damage to 1 dps per stack like it was in patches 4.10 to 5.5; That would lower his max expunge true damage to 36 levels 1 through 3.
For a harder to understand mechanic, but one that is closer to my intentions, Expunge could do the exact damage Deadly Venom would have done over its remaining duration, rather than the damage it would do over 6 seconds - this matters quite a bit when Twitch doesn't expunge till several seconds since he last attacked.
I think this is the kind of love Twitch needs to get back on his feet, not slow reversal of nerfs to his stealth as an escape.
(This is an offshoot of my post about the future of Jungle Twitch, here)