We need a Plague Mage
Throws around disease and infection. Builds AP, but deals physical damage.
One form of attack causes disease to spread across adjacent units over time. Think of it as a cross between Malzahar's malefic visions and Sivir's ricochet.
Another form of attack causes infection that applies DoT and grievous wounds. Think of it as a more interesting variant on Gangplank's grog-soaked blade.
Applying slows, blinds, and vulnerability to physical damage would be thematic as well. Blind is a highly under-utilized form of CC, so more of it would be a good thing.
Hmmm, this champion may be better as a support. Sort of the anti-Soraka.

nuff said
AIDS
combine these 2 then add Fizz's W and we're set
don't think riot's gunna make any more blind champs doe.
"neuuuu"
would probably be a must. 1 dot = armor shred. (one reason Darius' bleed is magic dmg and not physical)