XCOM "Viper" Cassiopeia?
Since Cassiopeia is considered a very spammy champion when it comes to her abilities I figured, why not simply draw inspiration from one of the more popular and recent snakelady themes right now?
There's a special unit called the "Viper" in XCOM 2 that makes use of a plasma rifle to shoot green explosive projectiles. Cassiopeia for example could cast abilities like Noxious Blast or her Twin Fangs by using such a weapon, just imagine the hilarity once she starts gunning someone down. The Viper also is capable of spitting miasma-clouds of her own, just like Cass.
Wouldn't you love a high quality skin for her which significantly changes her mode of attack by introducing a futuristic weapon? She could wear some cool sci-fi gear, too - maybe even make it a PROJECT skin. I'd just love to see her receive some much needed recognition after all those years of negligence (it's been over 3 years since her last skin), she could really use a legendary skin of her own at this point.
Anyway, here's the "Viper" I was talking about. Just imagine Cass in that kind of getup. http://i.imgur.com/EE4DqOQ
" for ya