Uninspired suggestion but... how about a skillshot Rune Prison?
As everyone has noticed, Ryze is seeming kinda impossible to balance right now. He's swung from 40% win rate to 70% ban rate and back to 40% win rate without any sort of happy middle. I think a big part of this is the fact that Riot added a skillshot to him in his rework... but it was his Q. And there's not much point in his Q being a skillshot when a perma-root makes it impossible to miss anyway.
Why not make Rune Prison a skillshot? It'd actually give some counterplay to the 'perma-root and murder' playstyle that everyone hates so much and it'd feel a lot less pointless than making Overload a skillshot that you have no reason to ever miss in a 1v1 anyway.
Normally I think "make X a skillshot" is really lazy, I don't actually mind targeted abilities as a whole. But Ryze's problems seem to be almost entirely based around the fact that he can reliably chain CC on someone so that they have to tank his damage. Why not make that less reliable?