A Note to Riot and Players: The More % Health Damage Someone Has, the Tankier They Will Build
This is due to the fact that the champion's damage scales with the enemy's defenses, meaning they already have innate damage scaling beyond leveling up. It's like having an item already strapped onto your kit that boosts your damage, so you if you wanna have a balanced build, you will get a defensive item on top of it. Champions who have flat damage won't scale with their enemies' defenses. Therefore, they need to rely on ratios and therefore bonus AD and AP to have their damage remain effective throughout the game.
Remember this when designing and playing new champions. If you want someone to be a Bruiser, give them % based Anti-Tank options and a few moderate ratios to make them build majority tanky. If you want someone to be a pure Tank, give them all flat damage, but absolutely no decent ratios to discourage them from building damage. If you want someone to be a Assassin/Damage-Based Mage, give them flat based Anti-Tank options and good ratios to make them build majority damage with a small amount of tank, if any at all. If you want someone to be a Marksman, give them a tiny bit, if any Anti-Tank options and great ratios, but make sure they have sustained damage, in order to make them build full damage to make sure their DPS remains consistent throughout the game. If you want someone to be a Support, you will have to go kit to kit and inspect what exactly they need to make them be built Support.
NOTE: I'm not saying DON'T give someone % Health damage or DO give someone % Health damage. I'm just saying be prepared for what USUALLY comes with it. I'm also not saying that IF a champion has % Health damage, they will build tanky. It will just push them in that direction unless something else forces them or provides a better reason to build damage.
,
, malzahar did it once but he had no incentive with most of his damage in AP ratios, sejuani (who was nerfed for it ), nasus(though his entire kit encourages it),
(was actually a thing once but it fell off in favor of dps marksmen),
(this...should...never...be...tanky),
(had a kit where he had little choice but to build tanky unless he went hybrid or full AP...his Q was so funny to do that with XD),
(his whole kit was based around AD and AP ratios but his most efficient build was tank and i've not kept up but it still seems to be)

...all on the same team.
Tank Vayne is possible, but people prefer crit one.
giving a mix of durability and damage and probably some additional damage items which scale well with the particular ADC .... such a build would probably work quite well 1v1.... however a normal ADC build deals way way more damage and is much more useful in teamfights where the ADC is usually protected and relied on for damage
Had the highest percent health potential in game and built squishy for the most part