Getting rid of runes and masteries was possibly the stupidest choice Riot ever made.
Old runes and masteries made it possible for a whole host of characters to be viable, because you could target specific weaknesses and cover them using both OR enhance their strengths. The new runes don't do any of that. Not only that, there are fewer of them to choose from and they aren't even properly balanced in relation to each other. The only possible reason for runes to exist in the state it is right now, is that they're easier to balance because there's fewer of them (ironic, since they still aren't). No wonder people keep picking the same characters over and over again and no wonder the game is just not fun anymore. Variety is dead and with Mobas, variety is exactly what keeps people coming back.
I don't know what made Riot think Runes Reforged was a good idea, unless their plan WAS to make a select group of 30 some odd champions be the only viable characters in the game. If they have any sense, they'll revert back to the old system. This won't happen though, because that would require them to admit they made a mistake.
and
your runes and what you want out of them are going to be dramatically different for each champion, because theyre different playstyles entirely.
Malzahar? I take red/white as my runes (predator and magic feet)
Nocturne? Red/yellow. (Hail of blades and overheal)
Mundo? Yellow/red (Conqueror and ravenous hunter)
Chocho? Green/white (Grasp, demolish and magic feet)
Leona? Green/red. (Aftershock and ultimate hunter)