Inhibitors fall and games are over at the 10 minute mark
If you play a character that has even a faintly weak early game, you lose in this meta. And with there being no early game defensive options with the new runes, anyone that isn't a hyper assertive lane bully is going to lose early game.
Nexus is literally falling at 13 minutes because towers aren't even made of paper at this point, they're made of sugar glass. Early AD is stronger than ever and tank supports are forced to the back lines for fear of being instantly deleted for daring to try and use
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If you aren't winning your lane by 5 minutes, that inhibitor is forfeit.