Wit's End buffs for melee do literally nothing.
I like that your guys are trying to get this item somewhere for anyone who isn't Kog and Varus, but i think it needs something very different. I really tried to find someone it would be good on with the buffs but i just can't imagine ANY melee champion wanting this over something else, not even the ones who've used it in the past, since there are just so many better items now; Triforce, Steraks, Titanic will be a better choice for melee dmg every time. Jax base damages are high enough that what he really needs is to survive in tf's and Titanic Sterak's is just plain better for that, and if you go for burst jax wit's end doesn't fit the build. Shen has much better options nowadays with Titanic then he did back when he used the item, + his rework gave him more health ratios than before, meaning purchasing this doesn't increase his dmg output as much as before the rework, compared to just getting more tanky.
And well.. No other melee champion has any reason to EVER buy this item tbh. Think it needs a specific rework if you'd want it to be viable again, maybe throw in a phage and make it a 3300g Item or something like that, maybe reduce the attack speed a bit, and i could see it being at least mayyybe viable on jax or shen? But yea outside of fringe abuse situations by rageblade adc's i don't see this item ever being good without an actual rework. At least not while remotely balanced.
seem to give a really solid mix of mixed defenses and a huge damage threat.