You can't last hit with ryze when you're playing under tower

Good thing his spells are on like a 1 second cooldown.

Natural Talent (+AD) Savagery (+5 bonus damage to minions/monsters on AA and single-target spells) Q (40 mana, single-target) E (40 mana at rank 1, single-target)

It's the same for all champions (earlygame, talking base AD + runes): AA > Tower shot > AA

For melee minions: Towershot x2 > AA

last hitting with basic attacks as ryze... instead of using e q combo to 1 shot teh whole wave... logic.