The Rejuvenation Bead + Machete Start on Warwick Got Me Thinking . . . Long Sword + Bead on Laners?
Could this be worth on some champions, so replacing the obligatory reffillable pot or 3pot with a rejuvenation bead? Sure, you would be weaker in lane but if you don't plan to trade early on anyway it might just get you you an early Tiamat spike 150 gold faster than usual, so about one minion wave.
For example, you are 
against 
, where trading very early on is super risky but you will easily beat him once you got a few items and levels going. Since you wouldn't want to trade with Darius early on anyway and you got the tools in your kit to not let him force it onto you, you just farm minions in the early game and you don't necessarily need the extra pots. With this start, you would get the Tiamat spike one wave earlier and you would get to the point where you outscale Darius and beat him in trades and duels much faster.
This is just one example but I think it could work on a lot of other champions too.
from time to time, since it gave a really fast Tiamat.
is a much better rush on most champions.
and pots when I was facing Ap top as I thought the beads formed some sort of MR item( can't remember) but it was better than 
because the 80HP is great, but the regen wasn't better than having 2 beads that actually formed an item and I think with 2 beads it said I would get more HP per sec with pots so I choose the beads over shield.