Theorycraft time, which new rune/mastery will cause the biggest issue?

How can you theorycraft when we barely know like 3 separate runes in the new system?

i feel like the overheal one will be a huge problem

One i see is the marksman causing more black cleaver abuse issues with the overcap cool down rune. They can safely go for ER+zeal item+BC+DD, knowingly overcapping their cdr but now gaining more offensive benefits, and much improved defensive benefits, pushing out the niche usefulness of the last whisper items.