100 stacks over the course of a game creates a lot of HP..... and she can take
and the new Spellthief for more HP. Keep in mind she has current % HP of target damage in her passive as well.
She doesn't outrange turrets until 100 Wisp stacks and a RFC (which isn't optimal every game). Most games are over by then. (You've been watching too much BunnyFuuFuu videos where he pleads with his PBE teams to stay and take the punishment so he can upload a massively loaded video where he got every WIsp possible)
The point of mentioning Demolish is because of high mastery use. Q doesn't require a long action delay and reloads an auto. In other words, high mastery players can actually do drive by demolishes without risking prones. They can be chasing a lane opponent they are bullying, and literally Q the turret on the way back out, to be able to soak 1-2 more turret shots through her Q heal, AND do a chunk of turret damage.
Grasp actually stacks faster on Senna than Dark Harvest does, ends up doing more damage, AND has much larger lane bully characteristics.