Ap Varus anyone?
I just can't express how much I love playing this way. If you play right and have a great laning phase you can stack up tons of kills and snowball out of control. He's got major cons like the lack of mobility whatsoever as well as missing out on his Q's poke damage, but he makes up for it in team fight damage all around. With this build as well as my runes I was able to hit upwards of 2.0 attack speed on minion kill while still keeping massive amounts of damage to all champs I could affect. Your autos deal probably mid game adc damage and your ult is capable of one shotting squishies with at least 2 stacks of blight. And I feel like with the upcoming Varus changes this could further make AP Varus a better pick.