Do not start refillable potion on Kha'Zix Jungle.

For a few games I went this route as the game suggested and swapped out talisman and machete in different games. Honestly machete and 3 pots is a lot better than a refillable potion. As enticing as this item sounds to never have to buy potions again, I found the 3 pots far more effective. What made me decide this is I was ALWAYS too low to do anything after clearing one side of my jungle with refillable potions. I got gimped into having to buy a hunter's potion just to survive on my first back and couldn't afford anything else. Kha'Zix's early game after clearing one side of a jungle I feel is one of his strongest points in the game if you get the right picks. You can easily secure kills early if you play smart, and having the three pots I could still retain 1 pot after a first clear with over half hp, gank, and go back to clearing. This allowed me to have enough gold to get my jungle item on my first back as well as two long swords if I do very well.

tl;dr Refillable potions gimp you into hunter's potion on your first back with no gold left to spend. You miss out on lots of early game presence and waste time.