What a blatant load of bullcrap.
Let me correct you: Ryze has a single (1) (one) skillshot on his Q. But that doesn't matter because he has an instant targeted root which can just prevent people from dodging it. HIs E is also targeted so there's no real skill involved in that part of his kit either. I guess you could argue that he does HAVE two combos. He can either E then W or E then Q. There's no incentive to do Q over W as your second cast, but it's there if you feel like it I guess.
His R is the only mildly difficult thing about his kit, but it's nothing I would use the words "mechanically and cognitively demanding" for. In fact, I couldn't help but laugh at that entire post until I realized you were serious.