With the new Armor/ MR updates, Karthus is GONNA need to be looked at eventually.
Hear me out here. With the new Randuins update, it now reduced crit damage, but it also reduced damage done by magic spells that have crit text. The most prominent Examples are Anivia's E (deals X2 damage to frostbitten enemies), and Karthus's Q (deals X2 Damage to Solitary targets). Not only that, but the MR items have gotten lower and give more MR to encourage tanks to buy more MR. Now I know that this is sort of a reaction to the AP item update a while ago and this is meant to counteract the AP Champs that abuse this the most, but I think this hurts Karthus the most simply because of the reduction of damage that his Q will do.
On top of that, we're getting more champs that have the ability to completely negate Karthus's ult Altogether: Bard's Ult Tahm's W Ekko's Ult Fiora's new W
Not to mention the already existing Champs that can dodge a karthus ult, but I won't get into that right now.
What I'm saying is, that if Riot intends to keep making all these changes, at least give my favorite lich some love so he can keep up with the rest of the champs!