Some of the issues I have with current runes:
Bone Plating - Ughhh I fuckin' hate this rune. According to League of Graphs, it has a 77% pick rate in resolve tree, despite having been nerfed several patches ago. It almost feels like an auto-lost lane when playing against it as certain champs because a lot of the times you go in to trade/poke Bone Plating absorbs a lot of the damage. I think it should be reworked rather than nerfed into unviability because then Demolish would take over again.
Triumph - Even more picked than Bone Plating, Triumph is taken 83% of the time in the precision tree, leaving Overheal and Presence of mind at under a 4% pick rate combined. This rune almost eliminates the tenseness of close fights because if you kill your enemy and you're ignited, are taking minion aggro, are being damaged by a passive, etc. it just gets essentially negated, which makes it pretty unfun to play against.
Coup de Grace, Last Stand, and Cut Down - If you don't play Kled, you probably didn't remember Last Stand existing, and I personally didn't remember Cut Down being a thing. Coup de Grace has a 76.7% pick rate in precision, in my opinion it's purely because that's the best of the 3 evils. I try not to take any of these 3 runes because even if they do make an impact, you don't even feel it. It's just some passive damage that often goes unnoticed, and for that reason I think the 3 of these should be reworked into slightly more interesting runes. (Or at least make Coup de Grace less dominating)
Domination - Electrocute is just too strong. I know they're making changes to it next patch but I don't think it'll really fix the problem.
Dark harvest: Very situational. It's taken on Miss Fortune and Kayn currently.... And that's all I can think of. Sometimes people will take it for some kind of cheese build but other than those situations I very rarely see Dark harvest being used.
Predator: Taken more than Dark harvest, but still not taken on a lot of champs. Volibear, Rammus, Hecarim, and sometimes Nunu among others for, again, cheese builds that are generally impractical in real-game scenarios.
Hail of Blades: Oh yeah, they added that into the game. Jhin takes it... sometimes...... Basically it's just a precision rune disguised as a domination rune. No champs who should be in domination should be taking it, and I'm not sure why Riot wants marksmen taking domination.
Other weird things:
Aftershock is taken 52% of the time (which isn't a lot until you consider there're 3 things to choose from). Maybe just nerf it a bit idk
Cosmic Insight is taken 63% of the time in inspiration which who really cares tbh
There are some other weird things but I spent too much time on this already tell me what y'all think
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removing the AoE slow in item actives and put it on your empowered AA or remove it and make the empowered AA ground the enemy for 1 sec would make this rune actually usable