So, with their cost reduced to 150G and the base Gold increased to 500G, you can get three and then a potion. Who could buy 3 
for 150% increased health regeneration early game?
Current List:
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(Sustainmerdinger?)
GetBoomedOn2 votesIn my humble opinion, it's a great sustain start for Renekton with the sustain masteries. He gets really hard to push out of lane with that and his Q plus it builds into Ravenous or titanic Hydra which is good on him.
Lost In Time1 votesAnd then build them into what?
Also, assuming the average champ has like 2.5 regen per second at level 1, you have now 3.75 per second. Wow, game changing.
GetBoomedOn1 votes[{quoted}](name=Lost In Time,realm=OCE,application-id=3ErqAdtq,discussion-id=5mXpEphL,comment-id=0000,timestamp=2015-11-16T16:48:09.540+0000)
And then build them into what?
Also, assuming the average champ has like 2.5 regen per second at level 1, you have now 3.75 per second. Wow, game changing.
or
then 
possibly later on.
Also, you don't really use the hp regen at level 1. After a few waves the HP regen grows as you level, so you really start to benefit more from level 3-4 on.
Best Darius KR1 votesFirst thing that comes to mind is Titanic/Ravenous Hydra, and then an item which build from Cristaline Bracer, maybe Warmog's or something.
Meep Man2 votesThey actually build into a variety of items that Fighters can make use of, such as 
and . Tanks as well.
You also forget that this also increases health regeneration per level by 150% as well.
Tim Johnson2 votes[{quoted}](name=Lost In Time,realm=OCE,application-id=3ErqAdtq,discussion-id=5mXpEphL,comment-id=0000,timestamp=2015-11-16T16:48:09.540+0000)
And then build them into what?
Also, assuming the average champ has like 2.5 regen per second at level 1, you have now 3.75 per second. Wow, game changing.
I mean, how stupid is this kid? First off, 3 beads gives +150℅ hp per 5 secs, so your monkey math of 3.75 should be 6.25.
Second, one of OP's listed champs is Darius, who rocks nearly 10 per 5, which would skyrocket to 25 per 5.
Third, add the tier 4 resolve tree mastery, and a Darius could be at 30 per 5... and thats only at lvl 1.
Consider that a pot regens 50 per 5... The beads are doing 60℅ of that, at ALL times. And they each sell back for only 45 gold net loss. Idiot.
venomous frost1 votesbetter of buying potion or dorans shield, hp regen is too low.
Lost In Time1 votesStill taking up a lot of slots, considering first back you'll want boots and a ward too, and if you been farming a bit longer than your Tiamat...
Plus zero offensive stats and hoping your enemy laner will leave you alone to regen (hint: just like Garen, they won't)
Meep Man1 votesThis leaves you with 2 open slots early game (3 if you use potion) for your Boots and Ward. Not to mention Beads build into Tiamat so you would only need one open slot for that.
I am more asking about which champions could sacrifice or dont want said offensive stats for more stick in lane.
Also, you would have to be pretty bad at last hitting to not get Tiamat first back with this, especially since you should be staying in lane for longer.
Spoofghoul1 votesOr you can buy 2 and start with
+ 
x4
+ x2 + 
Or 
+ +
Meep Man1 votesOr you can go 
and have 50G extra for upgrades.
I think the first and second ones are good ideas though.