Unpopular opinion...guinsoos is a terrible item
You have to attack 6 times to get the passive to kick in, and late game fights are so short you'll probably be dead before the passive even kicks in. You're better off just getting crit if you're an adc honestly (heck, even on Kayle I'd rather have crit than this). And yea the mixed damage seems appealing if the enemy is building armor, but if armor is the problem why not just get a last whisper instead? Finally the stats on this item are terrible and it's REALLY expensive. Want more proof it's garbage? Look at the 4 adc's with the highest winrates (Vayne isn't there btw). Jinx, Twitch, Ashe, and Sivir. Literally NONE of them have this item as part of their build. I rest my case
https://champion.gg/statistics/#?sortBy=general.winPercent&order=descend