General Tips:
- Q first is quick poke. You can abuse your passive + tumble distance to get into auto range and back off before they can meaningfully retaliate.
- Auto -> Q -> Auto/E for a full W passive proc. Alternatively, if you get two autos off, you can tumble for the third for the same reason as above, but be careful for turnarounds or retaliation since you just finished your skill rotation.
- Keep bushes warded for condemn opportunities.
- Your Q can be used to get in a better condemn position, but when simply farming save it for dodging skills unless you see an opening to exploit(back to first tip).
Itemization:
- A standard Vayne build is
->
->
, the last 3 items are situational
- If you're really ahead or randomly get BF gold from early kills before first major B, you can go
first 3. It feels clunky because of the lack of early attack speed, but I've done it with some success. More focus on Q poke, less on silver bolt procs until zeal.
- I've seen some players like Aphromoo rush
first item and have some success. Less damage, but easier time handling rough lanes because of the raw sustain (Warning, metasheep will flame you for this rush).
Synergy:
Vayne does best with tanky disruptors that can keep targets locked down long enough for her to melt them with silver bolts (or raw AD and Q damage), but also have strong peel potential; bonus points if they have direct utility. Think Thresh, Leona, Blitzcrank (this one is kinda cheese. Blitz pull from side of lane, Vayne condemn into wall blitz is hugging), Nami, Alistar, etc.