Would you play a "Machines-style" 1v1 mode?
For those of you unfamiliar with it, in Machines you were a general who could take direct control of any of your units anytime.
Since LoL already has an AI system, couldn't something like this be implemented?
Let me explain: a 5v5 game on Summoner's Rift with all champions controlled by the Intermediate AI.
During the match you can take control of any of the bots, and so can your opponent (each on his own team, of course). This way you could coordinate ganks, decide if pushing your advantage in a winning lane or try to defend a losing one, etc.
Besides being imho pretty interesting and fun, another point in its favour would be that it requires just 2 people, thus needs very few players for it to be active and queue times to be low.
(Obviously, you'd get to assign runes and masteries from your own pages, do all the banning, and assign lanes to the AIs)