I wonder if Riot could use Ridley from Metroid as a Champion inspirational source...
Fighting Meta Ridley on Hard/Hypermode in Metroid Prime 1 is one of the funnest boss fights in recent memory. He has many different attacks, hurts like crazy, and he's fast as all hell.
Case in point: https://www.youtube.com/watch?v=cQaorAbanC0
Sounds like a recipe for a Champion if I ever heard it.
Now, not saying we should be getting the space dragon himself in the game (even if Kayle has some Samus references), but if you were to use Ridley for an inspirational source, how would you develop him? Mechanized dragon from Zaun? That'd be cool.
(Note that this doesn't mean I would necessarily try to make him myself. It's just an idea tossed on the table.)