I am a firm believer in "it isn't over till its over"
But when every single lane on your team loses and is down by 4-5 kills each by the 10 minute mark, and you notice that its from them just being idiots or not competent at all with their champ/class, then there really is nothing that you can do. There is sadly no turning around a team that has 0 idea as to what it is actually supposed to be doing.
You can win a game when behind with a team that just was playing poorly early in the game. Happens all the time. but when your teammates are playing poorly because they in fact don't even know how they should be playing, then you should just call in quits at 20 and move on.
And the worst is when they don't even believe that they are out of it while their down 30 kills, 3 drags and 2 inhibs at 23 minutes and the enemy support can keep our team from doing anything.