I'm having issues keeping up with this game as my main, Annie. Sure, she's really simple to play and has some great close-range burst, but she just can't survive laning phase anymore without getting heavily bullied at level 3, then utterly destroyed at level 6. Just ask any Zed or Yasuo main. They see an Annie, they literally wet themselves when they hit level 6. They cannot WAIT until they find a good time to press "R" and delete her out of the lane. She's an easy score to them. Try to poke them back? They just all-in sooner now that you have no spells to counter.
Annie is a great mid game game champ, but she certainly cannot hypercarry a late game all on her own, even if fed she can be taken down by a 0/9 assassin who builds 1 item if she doesn't focus him first. If she DOES focus him first, the useless feeder, then the enemy 7/3 Jinx that you -should- be dumping everything on will just then blast everyone anyway (and 7/3 is being hella modest).
Too many times I pop everything on a mid lane opponent at 6 and just barely get them to 25%, meanwhile they return the favor and I'm the dead one. So my girl is now just basically a no-lane roamer and sacrifice farm and your tower to make it to late game and be somewhat relative with the lanes you helped during laning phase.
You stay in lane as Annie, you will eventually just get dunked by more than 80% of mid champs of today. There's way too much damage for the health bar to handle these days. Even as a burst mage main I don't expect to just 1-shot people, but when I am the one who gets 1-shot by a Lux who snags a lucky q on me with a damn blasting wand, or a Zed with 3 long swords, when I cannot 1-shot them because I have to rush boots to avoid being poked to oblivion and roam, that makes me feel just salty as a Ritz cracker. I do not like this rune system. I wouldn't mind or miss it if it was simply accidentally deleted one day, but it would be silly for me to say that is the main cause of the problems with this game. There's too many to be listed sensibly, compared to Season 2. Game has always had problems, sure, but never to this extent. This is someone who poured 9+ hours a day into this game, every single day of the week now can only barely do 1 hour a week before I get too frustrated for my own health.