I've been in a two vs one lane so I will say playing safe is still an option. if they can easily tower dive, farm jungle. if you can't farm jungle, you messed up or you have a troll on your team just feeding him 5 kills really early on.
if you are ashe, spam volley to poke and play safe. if draven gets ahead, that's something you want to avoid in the first place, but if it happens, just farm it out as much as you can and hope for the best. if your support is just feeding or something, then first tower will fall and then you have to hope other team doesn't push too hard and take everything. basically you would be hoping to delay the game at this point until you get your items.