The only reason Sated Vayne hasn't gone fotm

Is that idiots keep trying to build her glass.

You can go as your only damage items and still do an utterly absurd amount of damage, while leaving room for etc.

Cannot be bursted down because tanky. Cannot be dueled by bruisers because massive %hp true damage. Cannot be dueled by squishies because she's too durable. Can't even catch her out and focus her effectively.

The only thing you can do is hope she's stupid.