Lord Dominick's Regards means that there is no good way to build against ADCs.
If you're playing a champ that has high damage ratios, the closest you can get to building defensively against an adc is to go full damage/pen and blow them up before they click on you.
If you're playing a tank or a juggernaut and the enemy adc reaches their 3rd or 4th item, your game is over, because you invested in stats that are now completely irrelevant against a ranged damage threat. You can't participate in team fights until someone else kills the adc. Or you can die securing the adc. Either way you're leaving your team without a frontline.
It feels fucking awful.
-point and click cc