Make Lethality a Melee stat which means : can't be bought by adcs. Adcs should be sustained damage carries not ranged assassins.
Make Dark Harvest Deal 50% less damage on ranged hits so : can't oneshot you with 1 AA.
If they need adcs can still get .
Make her E CD longer. Make the hitbox smaller. Reduce the size of the bubble so she can't trap you with nowhere to go easily. Keep her Q the same.
And please reduce the overall damage.
Trancendence rune needs to cap at 30AP or AD. So they can stop stacking CDR items. Like tank , can cease to exist. Don't just nerf the champion because changes you implemented broke them.