New permanently consumed items?

I'd like to see new items like Eleisa's Miracle but specifically aimed to counter certain things in the game. For example a weighted backpack that reduces your movement speed but also knockup durations, a steroid pill that grants additional (temporary) 'fake' health (for example 20% of your maximum health) after taking a lot of burst damage (for example 40% of your maximum health within 3 seconds) that reduces health regeneration to nothing and kills you when it runs out if you don't have health of your own left except that 'fake' health, maybe also a tenacity item?

Of course it'd have to be expensive to be balanced.

EDIT: The steroid pill additional 'fake' health gets used last on the health bar.