A few balance changes I'd make to items

: 50 MR -> 45MR; 2350g -> 2400g; : 6% current health -> 8%; : Block 8 dmg after reductions instead of before reductions; : 10 ArPen -> 15 ArPen; Passive Flat Dmg 90 -> 10xLVL; Passive CD 120 -> 90 : 65 armor -> 60 armor; 500 mana -> 600 mana; Sheen proc 125% base AD -> 100% base AD; : up to +15% physical damage -> up to 20% autoattack damage : 30% max health shield -> 50% bonus health shield : 70 MR -> 60 MR; 2800g -> 2900g; : 70 MR -> 60 MR; Shield refresh CD 40s -> 30s : 65 AD -> 70 AD

And these are only a part. I find Guinsoo not in need of heavy nerfs. Magic Resistance needs nerfs all over the place. Tankyness must be easily addressed by autoattackers (hence the buffs to Botkr and Lord Dominik's), not by assassins (that's why I'd restrict Lord Dominik's passive to AAs). Duskblade feels pretty underwhelming, I see it more as a means to pour snowball gold for assassins into a vaguely effecient item slot than as a resource in itself. The buff to IE is to give DPS Adcs a slightly better time in the midgame.