I'll give you an honest answer: It's because Mechanically, if Diana HITS you, she probably hits you with every single part of her kit. It's unavoidable once she hits a Q and is range.
What I mean is:
She hits you with all 3 orbs from W on Ring in.
She hits you with multiple R's after you are hit with Moonlight from Q.
She hit you with Q.
Most champions give you a little lee-way if they miss a skill or two when built on hit, because some part of their kit is a skill shot or something. In Diana's case, the only part of her entire kit that isn't 100% guaranteed to hit, is her Q, and that's her initiator......
Ie...... most champs have the capacity to kill 50% Reduction champs TWICE in their damage output per kit. Diana's kit nearly guarantees it.
Ways around it:
-Move speed to avoid the Q's.
-Ways to heal mid combat, like
's W
-Dashes/Flashes to avoid the spheres when she R's in, and hopefully get far enough away that her E can't pull you back in.
You can also get
. Her kit relies on multiple hits from the same spells, so this is actually an extremely strong item versus her. W hits three times, and R can proc 2 times per moonlight. Adaptive significantly mitigates some of that.
There's also a very risky thing you can do while Diana is engaging:
Her R is NOT a Blink. You can skill shot her with a hard CC and it will disrupt her R. After that, she's worthless for 4-5 seconds.
P.S. a Good Leblanc... you will not survive with 100 mag resist unless it's VERY early game lol.