Offensive Masteries Review & Math
So a lot of people blindly go 21 offense for a lot of champions, so lets do some math
Havoc - 3% Damage This means if you deal 2000 damage to someone, Havoc increases it to 2060
Devastating Strike - 6% Penetration The higher the enemy armor the better this is, at low level it increases your damage by around 1% and about 5% vs 300 armor note becomes less effective if you reduce/penetrate the enemy armor, so last whisper etc reduces the effect of this mastery
Warlord & Archmage - 5% AD/AP AP is easier, just increase your AP ratio's by 5% or 6.5% if you have Rabadon So example, Annie combo is 900+2.5 AP ratio, it becomes 2.625 So at 500 AP, your total damage is increased by about 11% AD its harder, but in general auto attackers and AD scalers its worth it
Martial and Arcane Mastery - 4 AD / 6 AP ~140 gold of stats
Brute and Mental Force - 10 AD / 16 AP ~360 gold worth of stats