Are they worth taking on any champions? I think I used to use them on Corki and it was ok. Same with life steal, those useful anymore?
Just re doing my rune pages and trying to include anything that could be useful, even if very situational.
Very Hard Engage1 votesthey're ok on champs who deal mixed damage. but mainly they're for the early game mid laners who want to get solo kills. and they believe they're doing just as much damage with their autos anyway, so they may as well go for both types of pen so its harder for the enemy to counter build. (or counter rune)
also picked up by mixed damage jungle dealers like rammus, or shyv, it helps them out. i cant think of any others but im sure there are some.
Penns1 votes
Theyre pretty good on many champs tho.
Toastey1 votesHybrid pen reds are pretty ok on Fizz, Akali, and Nidalee, but they all benefit more from spell pen these days. It sounds pretty ok on Corki, but you'd be giving up flat AD reds, so last hitting early might be hard (unless you're used to playing AP Corki like me). You could make an argument for Hybrid Pen reds on some junglers. They work just fine on Gragas, so I'm sure they'll work for a bunch of other AP junglers too. Just remember to bring Attack Speed quints.
As for Lifesteal quints, they're only good if you're running 2+, preferably 3. They got nerfed a while ago, if you recall. They're still the staple quints on Yasuo, and you can use them for anybody with a Yasuo-type laning pattern if you want more sustain. They're pretty good on Fiora, especially mid. Off the top of my head, I'd say lifesteal quints would be good on Yasuo, Fiora, maybe Zed, and mayyyyyyybe Trynd (if your Q isn't doing enough work for you).
PiRoScOuT1 votesI like life steal on aatrox, and hybrid pen could work on kayle jax or eve
Laraso1 votesMaybe like, Kayle. Or Akali. Not many champions actually utilize them effectively.
Exiled Doll1 votesSona uses them pretty well since she AAs a lot due to her Q and passive.
ValyrianBlade1 votesHybrid pen reds can be good on AP supports who do a lot of auto attack poke in the early laning phase, as this will help you win a lot of early trades bot lane, while still giving a large portion of the magic pen reds for later in the game. e.g. Annie, Morgana, Lulu, etc...
Blastumz1 votesThey are the most overall efficient runes. Work well on a handful of midlaners and most ap junglers. Champs with shorter animation windows on their autoattacks like Syndra can take advantage of them in early laning.
Sohleks1 votesHybrid pen marks are quite effective on-hit attack speed type champions, particularly ones without AD ratios. Use attack speed quints with these and maybe take both flat ad and ap offense masteries for early game power
Maybe a few caster full tanks like these hybrid pen marks too
And maybe on some powerful early game mage types. It's really not necessary to rune hybrid pen over full magic pen though. Your AA harass will only do so much and it does pull creep aggro which is a tradeoff limiting how much you can actually AA
On some "hybrid" champions that have magic abilities who have ad ratios though you're probably better off with flat AD marks and AP quints.
Giving up AD marks hurts your laning too much.
Nekusen1 votesif you are just starting and/or low on cash and you use both AD and AP champions, they are the runes you want
Professor Ward1 votesthey work well on a few champs hybrid pen marks> mag pen marks if youre going to be auto attacking somewhat effectively
Stellafreyja1 votesI know it can be good for people like 
since all their abilities are magic damage but they also tend to auto attack a lot.
