Fizz continues to take the short end of the stick.

Fizz has always been heavily abused in lane, so abused infact that alot of champions can prevent him from getting CS from level 1, unless of course he wants to be forced to back by the time he hits level 2 because all of his HP is gone.

These runes make this experience so much more fun for fizz when every champion can now take an infinite use poke rune (Aerie) that can be proc'd on auto attacks and spells alike, and resets within only a couple of seconds. You WERE capable of enduring through the excessive and down right infuriating gameplay of games where you weren't even allowed to CS thanks to the old defensive runes, but now of course you're free to take all of that poke head on with nothing to protect you. No MR, no Armor, not jack.

But wait, there's more! Fizz's ONLY strength in the game atm is high early damage and a kit that translates into a potential snowball during the laning phase. You endure the totally interactive and fun gameplay that is early game VS a Ryze, Lissandra, Orianna, Cassiopiea, and Azir just to name the worst examples, then you have but a single damn opportunity to cheese them with high damage early and hope you can kill them. If you do then the only thing you can do is keep on killing and killing and killing just so you can actually have the lane to yourself. If you play in high elo VS players who actually know how to lane VS fizz they'll never give you the opportunity for this, and then they'll just stack defensive items against you leaving you no chance to win back your lane. You'll get choked on gold from the low CS, depending on the teamcomp no one will be realistically killable for you late game, and the mage mid lane will scale with their superior kit and impact the game for their team.

But this is a thing of the past. The fact that an AP assassin, a class of assassins that's already on the bottom of the barrel, can actually kill someone is appalling and down right toxic to "Player Experience". So Riot added a nifty little rune that acts as a mini hexdrinker to increase safety to Mage champions and further empower the downright broken and brainless defensive power that Hexdrinker offers as an early game buy for AD champions.

Now you can lose 1/5 of your HP bar every time you step up for a minion Pre 6 and if you dare try to trade there's not a snowballs chance in hell you'll have kill pressure on them. Infact, you'll probably just end up dying because you'll very likely be a significantly lower HP than them unless you choose to just chill at 0 CS from the beginning of the match.

This is why I stopped playing ranked so long ago. It was already bad enough in diamond elo dealing with players who knew how to abuse fizz, and because of his kit there really isn't much counterplay to the abuse. Now that issue is just becoming even stronger by the day with the new runes, even better itemization that counters fizz, and new champions constantly being rolled out with multiple hard counters to his kit.