Fizz: Fizz has several counterplay issues that need resolving, IMO; namely, that his passive gives him a free, low-interaction advantage against AD targets, making it feel impossible for them to punish or retaliate against him in lane. If he had a cooler passive that fit him thematically and didn't give him such an out-of-place advantage against physical damage dealers then that would just be a win-win overall, I think.
LeBlanc: As one of my favorite Champs, I'm hoping she'll get changes that will push her deceptive playstyle even further, but not to the point where it no longer feels like LeBlanc. Also hoping any changes she receives will put her in a better balance spot overall. Curious as to what her strategic niche will be after the update.
Zed: I look forward to seeing Zed's weaknesses and/or windows of vulnerability become much clearer post-update. He should have to make meaningful tradeoffs for his reliability and safety as an Assassin, and 'delayed burst' just doesn't strike me as one of them. Thematically, though, he's a cool Champion so I think he's fine in that department.
Talon: I just think this dude could be a bit more cool and unique all around with the right changes; currently, he's all about blades but has little else going for him. Maybe if he had some utility to offer -- or perhaps a bit of added safety during assassinations -- he could actually boast of more 'high moments' in his kit while having a way to GTFO once he's done killing a squishy target.
Rengar: No more 0.0000025 second one-shotting, please.
Akali: See Talon.
TL;DR: Most of these Assassins could use changes that push their thematic further while allowing for cooler and fairer interactions in-game. Hoping that each one will have clear reasons to be picked over the others come the update.