Vlad's only strenght currently seems to be not dying. He can survive fights... and that's it. His DPS is terrible and his team utility took a noticeable hit. Hell, even his sustain which is supposed to be THE strong point of his kit sucks as it is tied to huge delays.
Cassio... well, I like how they are focusing on making her revolve around their poisons. But why the hell does her Miasma have a minimum range? Would Riot's balance team just drop dead if they for once made a mage whom Zed can't kill and get away without reprecussions?