Not really scared, I'm just trying to theory craft the best champs to use it.
The best ultimate for this abilities probably have a low to mid range CDR. (Too low, at it could be trivial. Too high, and you won't be able to stack it.) I would also assume that the opportunity cost of this rune, would be higher scaling on said ults. So the best ults for this particular rune would likely have a strong mobility, CC, or utility component. And because you want to cast the ult multiple times, I would assume the ult would be best if used proactively, rather than reactively.
This in mind, Which champs or class of champs would fit this bill?
I would probably include many Vanguards and Divers who are pretty ult reliant for starting engages. (Older tanks like Malphite for example, Vi also comes to mind.) Particularly when Jungling, as it will allow for more powerful ganks more frequently.
I would also think that Assassins who have strong damage or damage amp ults, or ults that include invisibility or untargetability, would allow them to pull of their big burst combos more frequently. (Thinking along the lines of Talon, Zed, and Kayn (SA form)) I'm not so worried about Ekko, because his ult is often more reactive, and could be a little more difficult to stack.
I might also include a certain class of what I call "Engage mage," who are reliant on their ults for teamfights, causing lots of damage, and possibly disruption. (Annie, Fiddlesticks, Lissandra, Kennen)
Lastly, Most supports, who rely more on their ult's utility than its damage.