I'm a Twitch main and I win every fight, every lane, so long as I have a competent support. Wanna know why? Because my E, at 6 poison stacks, is dealing 110 base damage level 1. Most ADCs have around 5-600 base HP. At level 3, I can stealth in and kill any ADC at all ever if their support isn't there to back them up. Stealth, walk behind them, reveal, aa aa w aa aa e that's probably a kill. if not, just auto them until it is, get the stealth reset, pop the stealth, get out of dodge. Pretty much unless I decide to be dumb and stand up against a wall when I'm against a Vayne or something I can kill literally anyone level 3.