Underworld Twisted Fate & Wild Card Visibility
Technically this is a Skin discussion, but I'm putting it here because I think it has a pretty strong influence on gameplay.
I was watching LCS this week and noticed that Underworld Twisted Fate's Wild Cards (3-card skillshot) are translucent and really difficult to see (at least, when you're playing and not just looking for them), particularly in the middle of a fight or on certain areas of Summoner's Rift that have a greenish color similar to the cards themselves. You can see what they look like in a calm setting around 22:50; see around 25:00 for a more hectic setting. I really think this skin should be re-colored as soon as possible, as I have to imagine it is giving players who own/use it a significant advantage over players who simply don't notice the Wild Cards as quickly. (It's a Legacy skin, by the way.)
Of course, I'm sure there are a number of other skins that fall into this category.