If Skarner flashes with Hexflash, he can't use his flash (or hexflash) for the rest of the game
Pictures (thanks to Tempax on r/SkarnerMains): https://imgur.com/a/0Z0Ad
After you flash with Hexflash in your runes, your flash (or more specifically, the key your flash in on) is disabled for the rest of the game and is greyed out. You can't cast any summoner spells on that key for the rest of the game.