What is the best build for Vayne to do the most damage?

Im wondering what's the best item build and runes for vayne to do the most damage. I always build Botrk then Beserkers Greaves:Furor then PD first. After that, ive experimented with buying Ie, or buying a second Pd (for the crit build), or buying Trinity Force. I recently watched a vayne go botrk, beserkers greaves, two ies, and pd, and stattick shiv. She was 2 shotting squishies and even got a quadrakill that game. Does getting two ies work? Or should I trade one of those for last whisperer or BT?

As for runes I recently played a game with vayne where the entire enemy team were tanks, cept yasuo. Tank Ekko jg, Mordekaiser, Leona, and Tank Mundo. My build was botrk, Pd, beserkers greaves, last whisperer and a zeal. Last whisperer seemed to do nothing. I still did the same amount of damage. Do I need more AD for the last whisperer to work? Im wondering if i should include some armor pen runes instead of AD, AS, Armor, and MR.