It depends on your role.
If you're mid or top, you'll want probably armor seals (to stay in lane longer) and MR glyphs.
If you're ADC or support, you could take armor seals and scaling MR glyphs.
Also, if you have a lot of rune pages, you could break them down by matchup. So if you're mid against an AD mid, you could go scaling MR instead of flat MR glyphs.
AP supports are good candidates for hybrid marks. This is because they like the magic pen for their abilities, but a good support is AA-ing the enemy laners whenever possible, so the armor pen is good for poking down their health with AA's.
As far as Quints, it's what your champ does. AP mages like AP quints. AD Bruisers could take AD Quints. ADC's like Attack Speed Quints. Supports like Armor or health quints.
Also supports could take HP seals if they take Armor Quints.